Assistant Professor of General Pathology, Dipartimento di Biologia e Patologia Cellulare e Molecolare ‘L. Califano’, Università di Napoli Federico II.

Research interests
Molecular bases of insulin resistance.
• Signal transduction mechanisms of tyrosine kinase receptors.
• Role of protein kinase C isoforms in insulin and growth factors signaling.

Selected publications
Bifulco G, Di Carlo C, Caruso M, Oriente F, Di Spiezio Sardo A, Formisano P, Beguinot F, Nappi C. Glucose regulates insulin mitogenic effect by modulating SHP-2 activation and localization in JAr cells. J Biol Chem 2002;277:24306-14.

Andreozzi F, Melillo RM, Carlomagno F, Oriente F, Miele C, Fiory F, Santopietro S, Castellone MD, Beguinot F, Santoro M, Formisano P. Protein kinase Calpha activation by RET: evidence for a negative feedback mechanism controlling RET tyrosine kinase. Oncogene 2003;22:2942-9.

Miele C, Riboulet A, Maitan MA, Oriente F, Romano C, Formisano P, Giudicelli J, Beguinot F, Van Obberghen E. Human glycated albumin affects glucose metabolism in L6 skeletal muscle cells by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase C alpha-mediated mechanism. J Biol Chem 2003;278:47376-87.

Mondola P, Santillo M, Seru R, Damiano S, Alvino C, Ruggiero G, Formisano P, Terrazzano G, Secondo A, Annunziato L. Cu, Zn superoxide dismutase increases intracellular calcium levels via a phospholipase C-protein kinase C pathway in SK-N-BE neuroblastoma cells. Biochem Biophys Res Commun 2004;324:887-92.

Fiory F, Oriente F, Miele C, Romano C, Trencia A, Alberobello AT, Esposito I, Valentino R, Beguinot F, Formisano P. Protein kinase C-zeta and protein kinase B regulate distinct steps of insulin endocytosis and intracellular sorting. J Biol Chem 2004;279:11137-45.